New research suggests that stress experienced early in life, including during pregnancy and childhood, may increase the risk of developing digestive disorders later in life. In a study published in Gastroenterology, researchers found that early life stress can disrupt the communication between the brain and the gut, contributing to long-term gastrointestinal issues such as abdominal pain, altered bowel habits and gut sensitivity.
The Gut-Brain Connection
The findings highlight the role of the gut–brain axis, a two-way communication system linking emotional health and digestive function.
Researchers observed that early disruptions in brain development may influence how the gut functions over time, increasing susceptibility to digestive symptoms in adulthood.
What the Research Found
The study combined both preclinical and human data. In experimental models, early stress exposure led to long-term changes in gut sensitivity, motility and stress responses.
Human data further showed that individuals exposed to early life stress, including maternal stress, neglect, or adverse childhood experiences, were more likely to report gastrointestinal symptoms later in life.
Why This Matters
The findings suggest that digestive health is shaped not only by diet and lifestyle but also by early developmental experiences. Understanding these connections may help guide more holistic approaches to managing gut health, particularly in individuals with chronic or unexplained digestive symptoms.
The Bigger Picture
As research into the gut–brain axis continues to grow, scientists are increasingly recognising the role of psychological and early-life factors in long-term health outcomes.
While further studies are needed, these insights reinforce the importance of early intervention and supportive environments for both mental and physical wellbeing.
Source: Margolis, K. G., et al. (2026). Early-life stress alters gut–brain development and increases risk of disorders of gut–brain interaction. Gastroenterology.
Reviewed by: Dr Cheryl Yeo
Bio: Dr Cheryl Yeo is the founder of iAM Health. She has a PhD in food science and nutrition, dedicating more than a decade to research on metabolic disorders and weight management, functional food ingredients, and the science behind metabolism-focused supplements and microbiome-driven health therapies. Her work deepened her understanding of how targeted nutrition, including probiotics and digestive support, can influence long-term wellbeing.
Connect with Dr Cheryl Yeo: cheryl@iamhealth.sg or +65 80975612 (WhatsApp)